Entropic Tension in Crowded Membranes
نویسندگان
چکیده
منابع مشابه
Entropic Tension in Crowded Membranes
Unlike their model membrane counterparts, biological membranes are richly decorated with a heterogeneous assembly of membrane proteins. These proteins are so tightly packed that their excluded area interactions can alter the free energy landscape controlling the conformational transitions suffered by such proteins. For membrane channels, this effect can alter the critical membrane tension at wh...
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As pointed out in the main body of the paper, membranes are a crowded conglomerate of lipids and their partner proteins. Simple estimates of the extent of this crowding can be based upon an “average” membrane protein with a generic disk shape and a fixed radius from one protein to the next. Of course, membrane proteins are much more heterogeneous than indicated by such a simple estimate. In thi...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2012
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002431